Hepatoprotective Effect of the Methanolic Extract of whole Plant of Borreria articularis on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats


Affiliations

  • Kakatiya University, Department of Pharmacognosy, University College of Pharmaceutical Sciences and Ethanopharmacology, Department of Pharmacology and Toxicology, Warangal, Andhra Pradesh, 506 009, India

Abstract

The hepatoprotective activity of methanolic extract of Borreria articularis ( L.F) F.N. W illams: ( Rubiaceae ) at doses of 250 mg/kg and 500 mg/kg were evaluated by carbon tetrachloride (CCl 4 ) intoxication in rats. The toxic group which received 25% CCl 4 in olive o il (1 ml/kg ) per oral (p.o), alone exhi bited significant incre ase in serum ALT , AS T , ALP , TB l evels. It also exhibited significant (P<0. 001) decre ase in TP and ALB l evels. The groups received pretreatment of Borreria articularis at a dose of 250 and 500 mg/kg b.w.p.o. had reduced the AST, ALT, ALP and TB levels and the effects were comp ar ed with standard drug (Silymarin 100 mg/kg b .w.p. o).The total protein (TP) and albumin (ALB) levels we re signifi cantly increased in the animals received pretre atment of the extract at the moderate and higher dose l evels and the histop athological studi es also supported the protective effect of the extract.

Keywords

Carbon Tetra Chloride, Silymarin, Borreria articularis, Biochemical Parameters and Histological Study.

Subject Discipline

Pharmacy and Pharmacology

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References

Rajesh MG. Protective activity of glabra Linn on carbon tetrachloride-induced peroxidative damage. Indian J Pharmcol 2004; 36:284-87.

Pohocha N, Grampurohit ND, Antispasmodic activity of the fruits of Helicteres osora Linn Phytother Res 2001; 15:49-52.

Rajesh MG, Latha MS. Hepatoprotection by Elephantopus scaber Linn CCL4- induced liver injury. Indian J Physiol Pharmcol 2001; 45:481-86.

Anandan R, Deepa Rekha R, Devaki T. Protective effect of Picrorrhiza kurroa on mitochondrial glutathione antioxidant system in D-galactosamineinduced hepatitis in rats. Curr Sci 1997; 76:154345.

Chopra, RN, Nayar, SL, Chopra, IC. Glossary of Indian Medicinal Plants; CSIR: New-Delhi; 1956. pp. 39.

Ambasta SP. The Useful Plants of India; CSIR: New Delhi, 1986. pp. 78.

Mukherjee, KS, Manna, TK, Laha, S, Chakraborty CK. J Indian Chem Soc1993; 71:655

Mukherjee, KS, Manna, TK, Laha, S, Brahmachari G. J Indian Chem Soc 1994; 70:609

John a Parrott. Healing medical plants of peninsular India, CAB, International Publishing; New York, 2001. pp. 614-615.

Kirtikar KR, Basu BD. Indian Medicinal plants: 3rd ed. Vol. 2. 1988. pp. 162-1163.

Pedro A, De Sa Peixoto Neto, Maria Vladimilsa Silva, Nadja Corrente compos V, Zenaldoporfirio luiz C.

daetano Antibacterial activity of Borreria verticilata roots. Fitoterepia 2002;73:529-531.

Mukherjee KS, Mukhopadhyay B, Mondal S, Gorai D, Brahmachari G. Journal Chines Chemical Society 2004;51:229-231.

Kokate CK, Purohit AP, Gokhakle SB. Analytical Pharmacognosy, 5th ed. Nirali prakashan; India: 1997.

pp. 119-137.

Gerhard Vogel H. Drug discovery and evaluation: Pharmacological assays. 2nd ed Heidelberg: SpringerVerlag; 2002. p. 942-43.

Subramanian A, Pushpangadan P. Development of Phytomedicinesfor Liver Diseases. Indian Journal of Pharmacology 1999; 31:166-175.

Reckengel RO, Glende EA, Dolak JA, Waller RL.Mechanism of carbon tetrachloride toxicity.

Pharmcol Therapy 1989; 43:139–54.


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